Journal of Alzheimer's Research and Therapy
Advancing mechanistic understanding of Alzheimer's disease through rigorous investigation of molecular pathways, biomarker discovery, pathophysiological mechanisms, and translational disease models.
Decoding Alzheimer's Disease at the Molecular Level
The Journal of Alzheimer's Research and Therapy (JALR) (ISSN 2998-4211) is a peer-reviewed, open access journal dedicated to illuminating the fundamental mechanisms underlying Alzheimer's disease. Our mission centers on publishing high-quality research that advances understanding of disease etiology, pathogenesis, molecular pathways, genetic architecture, and translational models.
JALR serves as a platform for mechanistic discoveries that bridge laboratory investigation with translational potential. We prioritize research exploring amyloid cascade dynamics, tau pathology mechanisms, neuroinflammatory signaling, synaptic dysfunction, metabolic dysregulation, and genetic risk factors. Every manuscript undergoes rigorous peer review to ensure scientific validity, methodological rigor, and contribution to the mechanistic understanding of Alzheimer's pathophysiology.
As an open access publication, JALR ensures that breakthrough discoveries reach researchers worldwide without barriers, accelerating the pace of scientific progress in understanding this devastating neurodegenerative condition.
JALR publishes investigations that illuminate the molecular and cellular mechanisms driving Alzheimer's disease progression. Our scope encompasses pathophysiological research across multiple scales, from molecular interactions to systems-level pathway analysis.
Amyloid Cascade Mechanisms
Amyloid-beta production, aggregation kinetics, oligomer toxicity, plaque formation dynamics, APP processing pathways, secretase function, and amyloid clearance mechanisms.
Tau Pathology & Neurofibrillary Tangles
Tau phosphorylation mechanisms, microtubule destabilization, tangle propagation pathways, post-translational modifications, and tau-mediated neurotoxicity.
Neuroinflammatory Pathways
Microglial activation mechanisms, astrocyte dysfunction, cytokine signaling, complement cascade involvement, blood-brain barrier breakdown, and immune-mediated neurodegeneration.
Synaptic Dysfunction & Neuronal Loss
Synaptic protein alterations, neurotransmitter system dysregulation, calcium homeostasis disruption, axonal transport deficits, and mechanisms of neuronal death.
Genetic & Epigenetic Mechanisms
APOE variants, familial mutation mechanisms, genome-wide association findings, epigenetic modifications, gene expression alterations, and genetic risk factor pathways.
Metabolic & Mitochondrial Dysfunction
Energy metabolism disruption, mitochondrial impairment, oxidative stress mechanisms, glucose hypometabolism, insulin signaling defects, and metabolic biomarkers.
Vascular Contributions
Cerebrovascular pathology mechanisms, blood flow dysregulation, vascular inflammation, white matter changes, and neurovascular unit dysfunction.
Biomarker Discovery & Validation
Fluid biomarkers, imaging biomarkers, molecular signatures, prognostic indicators, mechanistic biomarkers, and multimodal biomarker approaches for understanding disease progression.
Animal Models & Translational Systems
Transgenic models, cellular systems, organoid models, in vivo pathway validation, translational model development, and mechanistic model characterization.
JALR offers researchers a rigorous yet responsive publication platform that values methodological quality, mechanistic insight, and translational relevance. Our editorial process is designed to provide constructive feedback while maintaining rapid turnaround times.
- Rigorous Peer Review: Expert reviewers assess scientific validity, experimental design, data interpretation, and contribution to mechanistic understanding.
- Rapid Publication: Average review period of 3-4 weeks with acceptance to online publication within 48 hours.
- Open Access Visibility: Unrestricted access maximizes readership, citations, and impact across global research communities.
- Global Editorial Board: International experts in neurodegeneration, molecular biology, genetics, pathology, and translational neuroscience.
- Transparent Process: Clear communication, constructive feedback, and author-friendly policies throughout the submission journey.
- Multidisciplinary Integration: We welcome diverse methodological approaches including molecular biology, biochemistry, genetics, imaging, computational modeling, and systems biology.
JALR welcomes multiple article formats to accommodate different research contributions and scholarly communications:
Original Research Articles
Novel experimental findings that advance mechanistic understanding of Alzheimer's pathophysiology.
Review Articles
Comprehensive syntheses of molecular mechanisms, pathways, or research methodologies in Alzheimer's research.
Short Communications
Concise reports of significant preliminary findings or methodological advances.
Methodological Papers
Novel techniques, model systems, or analytical approaches for investigating disease mechanisms.
Perspectives & Opinions
Expert viewpoints on emerging concepts, controversies, or future directions in mechanistic research.
Mini-Reviews
Focused updates on specific molecular pathways, mechanisms, or technical approaches.
JALR's editorial workflow is designed for efficiency and transparency while maintaining rigorous quality standards.
Expert Guidance from Global Leaders
JALR's editorial board comprises internationally recognized experts in Alzheimer's disease mechanisms, neurodegenerative pathology, molecular neuroscience, and translational research. Our editorial team ensures rigorous evaluation of submitted research while maintaining a constructive, author-supportive review environment.
Board members bring diverse expertise spanning molecular biology, genetics, neuroimaging, biomarker development, animal models, and systems neuroscience. This multidisciplinary perspective ensures comprehensive evaluation of mechanistic research across methodological approaches and investigative scales.
JALR operates on an open access model supported by article processing charges. These fees cover peer review coordination, editorial operations, production quality control, and long-term digital preservation. Our transparent fee structure ensures authors understand costs upfront, with waivers available for qualifying circumstances.
Advance Alzheimer's Research Through JALR
Join the global community of researchers decoding Alzheimer's disease mechanisms. Submit your mechanistic discoveries, biomarker investigations, or translational model studies to a journal that values scientific rigor and rapid dissemination.
